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鄭郅言

姓名職稱 鄭郅言 中央研究院合聘助理教授 鄭郅言
電　話 886-2-2789-8000 ext 34
傳　真 2782-6680
E-mail jycheng@gate.sinica.edu.tw
學　歷 Ph.D. Chemistry Department, National Taiwan University, TAIWAN, 1998
M.S. Chemistry Department, National Taiwan University, TAIWAN, 1992
B.S. Chemistry Department, National Taiwan University, TAIWAN, 1990
經　歷 Associate Research Fellow, RCAS, Academia Sinica, Taiwan, 2007, May -
Assistant Research Fellow, RCAS, Academia Sinica, Taiwan, 2001-2007
Postdoctoral Fellow, IBMS, Academia Sinica, Taiwan, 1998-2001
研究領域 Cell-based micro analysis：cell migration in weak DC EF, cell-cell interaction co-culture chip, cellular chemotaxis, electrotaxis and metastasis, affinity binding and separation.
Rapid prototyping of microfluidic biochip and their biomedical applications.
Microarray technologies： flexible in-situ array synthesis, rapid hybridization, mRNA labeling chip, and portable DNA amplification chip.
Laser micromachining – mechanism and applications.
相關網站 http://www.rcas.sinica.edu.tw/faculty/jycheng.html
著作與專利 Recent Publications│Patents


 Recent Publications

  1. Sun, Y.-S., S.-W. Peng, K.-H. Lin and J.-Y. Cheng* (2012). "Electrotaxis of lung cancer cells in ordered three-dimensional scaffolds." Biomicrofluidics 6(1)： 014102-14.
  2. Wang, C.-C., Y.-C. Ka, P.-Y. Chi, C.-W. Huang, J.-Y. Lin, C.-F. Chou, J.-Y. Cheng* and C.-H. Lee* (2011). "Asymmetric cancer-cell filopodium growth induced by electric-fields in a microfluidic culture chip." Lab on a Chip 11： 695–699.
  3. Huang, C.-W., H.-Y. Chen, M.-H. Yen, J. J. W. Chen, T.-H. Young and J.-Y. Cheng* (2011). "Gene Expression of Human Lung Cancer Cell Line CL1-5 in Response to a Direct Current Electric Field." PLoS ONE 6(10)： e25928.
  4. Hsiung, L.-C., C.-L. Chiang, C.-H. Wang, Y.-H. Huang, C.-T. Kuo, J.-Y. Cheng, C.-H. Lin, V. Wu, H.-Y. Chou, D.-S. Jong, H. Lee and A. M. Wo* (2011). "Dielectrophoresis-based cellular microarray chip for anticancer drug screening in perfusion microenvironments." Lab on a Chip 11(14)： 2333-2342.
  5. Cheng*, J.-Y., M. Z. Mousavi, C.-Y. Wu and H.-F. Tsai (2011). "Blue light emission from glass/liquid interface for real-time monitoring of laser-induced etching process." Journal of Micromechanics and Microengineering 21： 075019
  6. Hsiao, T. H., C. H. Lin, T. T. Lee, J. Y. Cheng, P. K. Wei, E. Y. Chuang and K. Peck* (2010). "Verifying expressed transcript variants by detecting and assembling stretches of consecutive exons." Nucleic Acids Research 38(20)： 13
  7. Yen, M.-H., C.-W. Huang, W.-C. Hsu, T.-H. Young, K. Zimmer and J.-Y. Cheng* (2010). "Crack-free micromachining on glass substrates by visible LIBWE using liquid metallic absorbers." Applied Surface Science 257(1)： 87-92.
  8. Microfluidic ARray Synthesizer (MArS) for Rapid Preparation and Hybridization of
    Custom DNA Microarray Ji-Yen Cheng* and Huai-Yi Chen, Biotechnology and Bioengineering, 2009, V104, p400
    [ DOI:10.1002/bit.22383 ]
  9. T.-H. Hsu, M.-H. Yen, W.-Y. Liao, J.-Y. Cheng* and C.-H. Lee*, "Label-free quantification of asymmetric cancer-cell filopodium activities in a multi-gradient chip ", Lab on a Chip, 9, 884-890.(2009)
    [ DOI:10.1039/b814405b ]
  10. C.-W. Huang, J.-Y. Cheng*, M.-H. Yen and T.-H. Younga, "Electrotaxis of lung cancer cells in a multiple-electric-field chip", Biosensors and Bioelectronics, 24, 3510-3516.(2009)
    [ DOI:10.1016/j.bios.2009.05.001 ]
  11. L.-C. Hsiung, C.-H. Yang, C.-L. Chiu, C.-L. Chen, YuehWang, H. Lee, J.-Y. Cheng, M.-C. Ho and A. M.Wo*, "A planar interdigitated ring electrode array via dielectrophoresis for uniform patterning of cells", Biosensors and Bioelectronics, 24, 875-881.(2008)
    [ DOI:10.1016/j.bios.2008.07.027 ]
  12. J.-Y. Cheng*, M.-H. Yen, C.-T. Kuo and T.-H. Young, "A transparent cell culture microchamber with variablly controlled concentration gradient generator and flow field rectifier", Biomicrofluidics, 2, 024105.(2008)
    [ DOI:10.1063/1.2952290 ]
  13. Cheng, J.-Y., Yen, M.-H., Hsu, W.-C., Jhang, J.-H. and Young, T.-H. (2007) ITO patterning by a low power Q-switched green laser and its use in the fabrication of a transparent flow meter. J. Micromech. Microeng., 17, 2316-2323
    [ DOI:10.1088/0960-1317/17/11/019 ]
  14. Yen, M.-H., Cheng, J.-Y., Wei, C.-W., Chuang, Y.-C. and Young, T.-H. (2006) Rapid cell-patterning and microfluidic chip fabrication by crack-free CO2 laser ablation on glass. Journal of Micromechanics and Microengineering, 16, 1143-1153.
  15. Wei, C.-W., Cheng, J.-Y. and Young, T.-H. (2006) Elucidating in vitro Cell-Cell Interaction Using a Microfluidic Coculture System. Biomedical Microdevices, 8, 65-71.
  16. Cheng, J.-Y., Yen, M.-H. and Young, T.-H. (2006) Crack-free micromachining on glass using an economic green laser. Journal of Micromechanics and Microengineering, 16, 2420-2424
  17. Wei, C.-W., Young, T.-H. and Cheng, J.-Y. (2005) Electroosmotic mixing induced by non-uniform zeta potential and application for DNA microarray in microfluidic channel (EI). Biomedical Engineering Applications, Basis & Communications, 17, 281-283.
  18. Wei, C.-W., Cheng, J.-Y., Huang, C.-T., Yen, M.-H. and Young, T.-H. (2005) Using a microfluidic device for 1 microliter DNA microarray hybridization in 500 seconds. Nucleic Acids Research Methods, 33, e78. Times cited： 8

    [ DOI:10.1093/nar/gni078 ]
  19. Kang, C.-C., Chang, C.-C., Cheng, J.-Y. and Chang, T.-C. (2005) Simple method in diagnosing cancer cells by a novel fluorescence probe BMVC. J. Chin. Chem. Soc., 52, 1069-1072.
  20. Cheng, J.-Y., Yen, M.-H., Wei, C.-W., Chuang, Y.-C. and Young, T.-H. (2005) Crack-free direct-writing on glass using a low-power UV laser in the manufacture of a microfluidic chip. Journal of Micromechanics and Microengineering, 15, 1147-1156. Times cited： 1, including 1 Research Highlight in Lab-on-Chip, Oct, 2005.
  21. Cheng, J.-Y., Hsieh, C.-J. and Chuang, Y.-C. (2005) Performing microchannel temperature cycling reactions using reciprocating reagent shuttling along radial temperature gradient. The Analyst, 130, 931-940. Times cited： 2, including 1 Research Highlight in Lab-on-Chip, Sep, 2005.
  22. Chou, R.-H., Lin, K.-C., Lin, S.-C., Cheng, J.-Y., Wu, C.-W. and Chang, W.-S.W. (2004) Cost-effective trapezoidal modified Boyden chamber with comparable accuracy to a commercial. Biotechniques, 37, 724-726.
  23. Cheng, J.-Y., Wei, C.-W., Hsu, K.-H. and Young, T.-H. (2004) Direct-write Laser Micromachining and Universal Surface Modification of PMMA for Device Development. Sensors and Actuators B：Chemistry, 99, 186-196. Times cited： 14. Selected in the Prominent Research Accomplishment of Academia Sinica, 2005 (94年中央研究院重要研究成果)
  24. Cheng, J.-Y. and Hsiung, L.-C. (2004) Electrowetting (EW)-Based Valve Combined with Hydrophilic Teflon Microfluidic Guidance in Controlling Continuous Fluid Flow. Biomedical Microdevices, 6, 341-347. Times cited： 1
  25. Cheng, J.-Y., Chen, H.-H., Kao, Y.-S., Kao, W.-C. and Peck, K. (2002) High throughput parallel synthesis of oligonucleotides with 1536 channel synthesizer. Nucleic Acids Research Methods, 30, e93.


 Patents

  1. "雷射無碎裂微加工 Crack-free Glass Micromachining Using Laser", Cheng, J.-Y., 鄭郅言, Yen, M.-H. and 顏孟華. (2007) 台灣 patent no. I271252.
  2. "生化反應晶片及其製法 Temperature Cycling Reaction Chip for Biological Reaction" Cheng, J.-Y., 鄭郅言, Hsieh, H.-J., 謝茜如, Chuang, Y.-C. and 莊永全. (2007) 台灣 patent no. I290954.
  3. “流體驅動裝置及其製法”, “Apparatus and fabrication of microfluidic driving device”, Patent Granted, Taiwan Patent No. 258456, Jul, 2006.
  4. "多管道寡核苷酸合成方法及裝置 Multi-channel Oligonucleotide Synthesis - Method and Device", Peck, K., 白果能, Cheng, J.-Y. and 鄭郅言. (2005) 台灣 patent no. I232867.
  5. “Apparatus and Methods for Chemical Synthesis”, Konan Peck, Ji-Yen Cheng, 2002, Patent Granted, US Pat. No.6,867,050.